Hes1 oscillations synchronize and refine condensation formation and patterning of the avian limb skeleton
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The forming limb skeleton serves as a signaling center for limb vasculature patterning via regulation of Vegf.
Limb development constitutes a central model for the study of tissue and organ patterning; yet, the mechanisms that regulate the patterning of limb vasculature have been left understudied. Vascular patterning in the forming limb is tightly regulated in order to ensure sufficient gas exchange and nutrient supply to the developing organ. Once skeletogenesis is initiated, limb vasculature undergoe...
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تاریخ انتشار 2017